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The three extracellular loops (most divergent in sequence), including the first two ones linked by a disulfide bond would participate in ligand binding (Metzger and Ferguson, 1995)
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In the previous study, teicoplanin (TIL) treatment significantly upregulated the relative hepatic expression of HSP70 and NF-κB mRNAs and blocked Nrf2/HO-1 mediated responses, indicating that TIL could induce oxidative stress and hepatotoxicity by blocking Nrf2 mediated defense responses and increasing NF-κB signaling pathways
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