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Negative Regulators of Adipogenesis On the other hand, high and sustained levels of KLF2, Pref-1, transcriptional-coactivator with PDZ-binding motif (TAZ), differentiated embryo chondrocyte (DEC), GATA transcription factors, and histone deacetylase Sirtuin 1 (SIRT1) inhibits adipogenesis and keeps cells at the preadipocyte stage
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