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Joint pain can also be linked to things like: osteoarthritis autoimmune arthritis (like rheumatoid arthritis) thyroid issues vitamin D deficiency side effects from medications It can also help to look at where the pain shows up: Swelling in hands or feet: could suggest autoimmune issues Stiffness in large joints like knees or hips: may point to osteoarthritis Sharp pain in tendons: could be from injury or overuse If your joint pain interferes with your daily life, it’s worth getting checked out

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Therefore, the observed effects on neurogenesis after systemic GDF11 administration seem to be indirect, potentially through activation of other factors in the periphery