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Their activation and incorporation into phospholipids are orchestrated by acyl-CoA synthetase long-chain family member 4 (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3), two critical regulators of ferroptosis (Dixon et al., 2015

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However, despite a sound mechanistic rationale, no NMDA receptor antagonist has yet received regulatory approval for tinnitus treatment, reflecting the substantial challenges remaining in this field (Che et al., 2025)