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3.2.2 ACPs derived from amphibians The skin secretions of amphibians are composed of various bioactive peptides, and hundreds of skin AMPs have been isolated from frogs and toads (Oelkrug et al., 2015), some of which also exhibited selective cytotoxicity against cancer cells ( Xenopus laevis skin, has demonstrated antitumor activity against human lung cancer and bladder cancer via forming pores on the cell membrane ( Litoria aurea , which was reported to exhibit high activity against 55 different cancer cell lines in vitro (Rozek et al., 2000
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Drugs targeting neurons alone often fail because they ignore the reciprocal signaling that glia provide
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