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Viruses-Basel 8 , 178 (2016)
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BENEFITS Melanocortin signaling — studied for agonist activity at MC4R and MC1R receptors Central pathway research — investigated for centrally-mediated effects distinct from peripheral pigmentation Cyclic stability — lactam-bridged structure constrains the bioactive conformation α-MSH derived — retains the core melanocortin pharmacophore Well-characterized — extensively referenced melanocortin research peptide WHAT RESEARCHERS LOOK AT Melanocortin receptor (MC4R, MC1R) binding and activation Central nervous system melanocortin signaling pathways Behavioral and neuroendocrine research models Receptor selectivity profiling versus other melanocortin analogs Structure–activity relationships of the cyclic lactam scaffold QUICK SPECS Form: Lyophilized peptide Net per vial: 10 mg Purity: ≥99% (HPLC verified) Identity: MS-verified (per COA) Storage: 2–8°C short-term, -20°C long-term, protect from light and moisture Reconstitution: Use (sold separately) bacteriostatic water IDENTITY BASICS Sequence: Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-OH (cyclic heptapeptide) Molecular Formula: C₅₀H₆₈N₁₄O₁₀ Molecular Weight: 1025.18 g/mol CAS Number: 189691-06-3 Common Synonyms: Bremelanotide, PT-141 WHY CHOOSE DURHAM PEPTIDES
