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In the 1 mg trial arm, liver fat fell 51% among participants with fatty liver, visceral fat fell 16%, and triglycerides declined.⁶ Ketones are a separate matter: the same substudy found β-hydroxybutyrate rose only at 4 mg and above, leaving the 1 mg arm without a ketone signal in that population.⁶ Modeled metabolic-health protocols place heavier, metabolically average profiles near 1 mg weekly