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Sub2 is synthesised during the asexual stage (Withers-Martinez et al., 2004) schizogony and is expressed during merozoite differentiation where it encodes an integral protein located in dense granules of merozoite (Barale et al., 1999), and possibly participates in the latter stages of invasion of erythrocytes
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Keratin 17 (K17) is pivotal in psoriasis pathogenesis: its abnormal overexpression drives excessive keratinocyte (KC) proliferation, inhibits apoptosis, and functions as an autoantigen to activate T cells, particularly Th17 cells, to induce the secretion of cytokines such as IL-17 and IL-23
