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The main manifestations are motor dysfunction, such as tremors, muscle stiffness, and bradykinesia
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Additionally, it was shown that P53, a significant gene in tumor suppression, has the ability to reduce SLC7A11 expression to inhibit cystine uptake by system x c − , thereby impairing the activity of GPX4 and leading to decreased antioxidant capacity, ROS accumulation, and ferroptosis (47)
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