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Exogenously administered or Gln-derived NH 3 stimulates the expression of the enzyme heme oxygenase-1 (HO-1) in human ECs (Figure 2)
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At the heart of SFN’s anti-CSC activity lies its coordinated interference with Wnt/β-catenin, Notch, and Hedgehog signaling - three evolutionarily conserved pathways that frequently become dysregulated in CSCs
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