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In a preclinical pediatric HCC model, inhibition of β-catenin activity using the ICG001inhibitor combined with sorafenib led to lower cell viability and showed synergistic effects, indicating that blockade of Wnt/β-catenin signaling may attenuate sorafenib resistance 114
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Specifically, the lowest loss of glutathione occurred at the applied concentrations of 0.1–1 mM (Fig
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