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Given the observed rates of excretion in urine and feces, about 20–25% is expected to be present in the organism at 168 h after administration, and about 30–35% of the dose has probably been eliminated given 3 H20 in expired air after metabolization of the test compound and isotope exchange with body water

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Overall, these findings underscore the complexity of the molecular interactions with the neural circuitry underlying anxiety and highlight the necessity for a multifaceted approach in the design of anxiolytic treatments