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this normalized glutamate acts on presynaptic type 2/3 metabotropic glutamate receptors to moderate pathologically elevated synaptic glutamate release (Moran, McFarland, Melendez, Kalivas, & Seamans, 2005)

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Keywords: central nervous system, GH, IGF-1, neurological diseases, somatotropic axis Introduction The somatotropic system, composed of extra-pituitary circuits and the somatotropic axis, ensures a balance between form and function in all organisms