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The recommended daily dose is up to 6 mg [153]

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While this has well-known implications for the development of atherosclerosis, more recently this form of metabolic dysfunction has been suggested to underlie pathologies such as age-related macular degeneration, not simply through the production of abnormal lipid deposits in areas where their removal is difficult, such as the subretinal space, but also by a concomitant increase in lipid-based free radicals (see below)