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The methadone dose may be split into q8hr or q12hr to improve analgesic efficacy (due to transiently higher drug levels following each dose, as a result of alpha-elimination)
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After identification of bacteria, different antibiotics, β-lactams (cefotaxime (Ctx), ceftriaxone (Cro), ceftazidime (Caz), cefixime (Cef), cefazolin (Cfz) imipenem (Ipm)), sulfamethoxazole (Smx) and ciprofloxacin (Cip), that were purchased from Sigma Chemical Company (Sigma Aldrich, Uk) at concentrations of 8–128 µg/mL were used to determine bacterial resistance
