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Moreover, BAFF mRNA was strongly upregulated in MS lesions, comparable to levels observed in lymphatic tissues, and BAFF was found to be expressed in reactive astrocytes, adjacent to inflammatory cells that expressed BAFF receptors (88) and the development of meningeal B cell follicles in progressive MS (89), astroglial production of BAFF may be a major factor to sustain these cells and to drive B cell-related pathology
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