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Modestly higher homocysteine, as predicted by genetics, was associated with an increased risk of stroke .[ref] High homocysteine levels can damage the endothelium (lining of the blood vessels) and cause hardening of the arteries.[ref] Related article : Heart disease genes Chronic diseases: Similarly, MR studies have shown that high homocysteine can cause metabolic syndrome , worsen osteoarthritis , increase the risk of cataracts, and increase the risk of Alzheimer’s disease