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The mRNA delivery of polymer nanoparticles can effectively induce the expression of Phosphatase and Tensin Homolog (PTEN) in cancer cells, based on this, the PTEN mRNA nanoparticles can reverse the immunosuppressive tumor microenvironment by promoting CD8 + T cells infiltration into tumor tissues and reducing Tregs and MDSCs, showing highly effective anti-tumor effects when used in combination with PD-1 antibodies (216)
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