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p = 0.52).66 Sixteen out of 25 secondary outcomes were met by the olamkicept 600 mg group including mucosal healing (endoscopic sub-score ≤1) at week 12 which was noted in 34.5% vs 3.4% (p 10 times selectivity for JAK1 compared to JAK2.81 The AMBER2 study was a phase II, double-blind, placebo-controlled study that randomized 164 patients with moderate-to-severe UC to receive ivarmacitinib 8 mg daily, 4 mg twice daily, 4 mg daily or placebo for 8 weeks.82 A total of 12 patients (7.3%) were exposed to anti-TNF/biologic agents in the past

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