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While macrophage-specific knockout of ATP citrate lyase stabilized murine plaques and showed dysregulated cholesterol and fatty acid metabolism, main effects seemed to be exerted via changes in apoptosis ( Fumarate accumulation in β-glucan trained monocytes increases histone methylation associated with an increased pro-inflammatory gene transcription of TNF and IL-6 (Liu et al., 2017)

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doi: 10.3389/fmed.2025.1644022 7 KcRShuklaSDGautamSSHansbroPMO’TooleRF