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The oxidized form (glutathione disulfide) and the reduced form (glutathione) transform one into the other in living organisms with the help of enzymes and the action of reducing/oxidizing agents

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The authors could confirm and extend the observations from the group of Lutz in so far as the clustering agent was only effective upon subsequent crosslinking of aggregated band 3 protein and only then induced binding of autologous IgG, deposition of C3c and phagocytosis (Turrini et al., 1991)