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Impaired autophagy determines IL-1β and IL-18 production by macrophages, thereby promoting the inflammasome activation (Saitoh et al., 2008)

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That enzyme is nicotinamide N-methyltransferase, or NNMT — a name that means almost nothing to most people, and everything to the small but growing field of researchers studying why fat cells sometimes get stuck in storage mode rather than burning through their reserves