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However, in some special circumstances or at special time points, treatment with GH may also increase DNA damage or decrease DNA damage repair, such as exposing GH to the GHD Lewis dwarf rats and Snell dwarf mice in prepubertal results in decreased DNA repair by leading to dysregulation of DNA damage proteins (Podlutsky et al., 2017)

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Many protocols include a maintenance phase with antioxidants, barrier-friendly actives, and follow-ups to reduce recurrence