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This was predicted to stabilise the N-terminal α-helix (5-18) of the peptide through formation of an intramolecular salt bridge, as observed in a crystal structure of CagriBB fused at the C-terminal end of maltose-binding protein (PDB:7BG0) 2
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The GLP-1 receptor appears throughout the brain, pancreas, and gastrointestinal tract, making it one of the most versatile metabolic targets available
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