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Its electronic structure result in formation of water by reduction with four electrons, i.e.: In the sequential univalent process by which O 2 undergoes reduction, several reactive intermediates are formed, such as superoxide (O 2 - ), hydrogen peroxide (H 2 O 2 ), and the extremely reactive hydroxy radical (°OH): collectively termed as the reactive oxygen species, the process can be represented as: For the production of O 2 - , normally the tendency of univalent reduction of O 2 in respiring cells is restricted by cytochrome oxidase of the mitochondrial electron transport chain, which reduces O 2 by four electrons to H 2 O without releasing either O 2 - or H 2 O 2
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FIGURE 6 MDL 74,405 contains a quaternary ammonium group
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