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10.1016/j.pharmthera.2011.10.006 306 ZhouJ.LiuT.CuiH.FanR.ZhangC.PengW.et al (2017)

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These are activated during the aging process due to an age-related redox imbalance where many pro-inflammatory signaling pathways [including MAPK and nuclear factor-kappa B (NFkβ)] lead to the formation of reactive oxygen species (ROS) [12,13,22,23,24,25]

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