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Pretty much all the research on the topic, though, says there are a lot of unanswered questions here, and more research is needed.[ref][ref] Related article : POTS syndrome genes Restless Leg Syndrome: A recent study found people with mast cell activation syndrome were about 3 to 4 times more likely than normal to have restless leg syndrome also.[ref] Related article : Restless Leg Syndrome Genes Let’s switch gears and look at how your genes may influence your risk of MCAS