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[36] Amongst these, electrostatic loop residues Lys136 and Glu133 are particularly important in directing the long‐range approach of incoming O 2 .− .[ 25b , 36 , 70 ] Arg143 also dictates O 2 .− orientation within the active site channel, and combines with Thr137 to limit the size of anions approaching the Cu centre.[ 25c , 71 ] Regulation of SOD1 antioxidant activity can occur via alterations to these and other key charged residues
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