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The circulatory system allows delivery of oxygen and removal of carbon dioxide throughout the organism

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The protein expression of ROCK1 and ROCK2 were significantly higher in hypertension-associated ED rats than that in the normal control rats, with a reduction of endothelial NOS, cGMP, and an elevation of norepinephrine-induced hyper-contractions, and acetylcholine-induced hypo-relaxations in the penile tissue [118]