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Figure 1 4 Drug delivery for Alzheimer's disease: formulations, ideal properties, systemically relevant effects, and delivery strategies of nanoparticles 4.1 Ideal physicochemical properties of nanoparticles for Alzheimer's disease 4.1.1 Size and charge Basically, for the treatment of AD and other central nervous system (CNS) disorders, nanoparticles with diameters of ~200 nm are considered optimal for the systemic pathway, as larger nanoparticles are more likely to be cleared by the reticuloendothelial system (RES) (Markova et al., 2022)