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Mechanistic studies have shown that MSU crystals can activate the complement system, including the alternative and lectin-associated pathways, with some evidence indicating the involvement of the classical pathway as well

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The peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha (PGC-1α) is proposed as a master regulator of mitochondrial biogenesis 11 , respiration, adaptive thermogenesis, and multiple metabolic processes 12