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Regarding ‘track’, the numbers quoted in the ‘critical review’ – pH of 7.4 to 7.5 20,000 years ago – came presumably from Figure S1 in the Rae paper, which provides an approximate conversion of the boron isotopes to pH
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The possible mechanism is that NAD + synthesis and breakdown are kept at a relative equilibrium state by NNMT to avoid superfluous NAD + synthesis from NAM in these cells
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