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When stimulated, it assembles inflammasomes with ASC, activates caspase-1, and caspase-1 cleaves Pro-IL-1 β to generate active IL-1 β , initiating an inflammatory response 26

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[DOI] [PubMed] [Google Scholar] 47.Giustina A., Ambrosio M.R., Beck Peccoz P., Bogazzi F., Cannavo’ S., De Marinis L., De Menis E., Grottoli S., Pivonello R