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Additionally, esculin (5-20 mg/kg) can ameliorate xylene-induced rat paw swelling by inhibiting the activation of the p38, MAPK, JNK and ERK1/2 signaling pathways and decreasing TNF-α and IL-6 levels (102)
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[DOI] [PMC free article] [PubMed] [Google Scholar] Kornblith E, Peltz CB, Xia F, Plassman B, Novakovic-Apopain T, Yaffe K
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