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Acknowledgements This work was supported by Brazilian Research Council (CNPQ, grant: 304833/2022-3), Carlos Chagas Filho Research Support Foundation of the State of Rio de Janeiro (FAPERJ, grant: 200.928/2021 and E-26/211.309/2021), Coordination of Superior Level Staff Improvement (CAPES, Brazil), Ministry of Health (Brazil), and Brazilian National Cancer Institute (INCA-Brazil)